TGFBR2 and Cirrhosis: Though it inhibits hepatocyte proliferation, transforming growth factor-beta (TGF-beta) induces the fibrosis in hepatic cirrhosis; in relation to aggressive characteristics of HCC, like IM, the expression of TGFBR2 (transforming growth factor-beta receptor II) may stand for an immunohistochemical biomarker for detection of aggressive HCC.