VWF and endothelial dysfunction: A study conducted by Karaman et al. [25] revealed that amlodipine (calcium channel blocker) and valsartan (angiotension receptor antagonist) improved endothelial dysfunction and vascular inflammation by decreasing the level of both Von Willebrand factor and NLR in newly diagnosed hypertensive patients, while similar type of work conducted by Fici et al. [26] demonstrated that nebivolol significantly reduced red cell distribution width (RDW), total leukocyte count, and N/L ratio as compared to metoprolol in newly diagnosed hypertensive patients over a period of 6 months.