Rohde et al. [23] found in pediatric BL a mutation frequency of 78% for ID3, 13% for TCF3, and 36% for CCND3. ID3 and CCND3 mutations were associated with more advanced stages of the disease and thus may represent a highly relevant second hit in pediatric BL pathogenesis (adult cases were not investigated). Here, TCF3 is linked to Burkitt lymphoma.