Cao et al. [22] investigated MYD88 and CXCR4 mutations in various IgM macroglobulinemia-associated diseases, including Waldenstrom macroglobulinemia (WM), various types of B cell non-Hodgkin’s lymphoma (NHL), MM, primary amyloidosis (AL), and monoclonal gammopathy of undetermined significance (MGUS): IgM monoclonal gammopathy-related diseases (IgM-RD). Here, CXCR4 is linked to B-cell non-Hodgkin lymphoma.