Of their cohort of 112 patients, 64 (57%) carried the MYD88 L265P mutation and 14 patients (13%) carried the CXCR4 WHIM-like mutation; MYD88 L265P in cases with WM (39/42), MGUS (8/18), NHL (14/41, including 4/13 DLBCL, 1/8 eMZL, 3/6 (sMZL), 1/4 chronic lymphocytic leukemia, 2/3 nodal (n)MZL, 1/2 MCL, 1 BL, and 1 B cell NHL that could not be classified), primary AL (2/2), and IgM-PN (1/1). This evidence concerns the gene MYD88 and B-cell non-Hodgkin lymphoma.