The PI3K alpha/delta (PI3Kα/δ) inhibitor AZD8835 showed marked potency in ABC DLBCL cells, whereas the protein kinase B (AKT) inhibitor AZD5363 induced apoptosis in PTEN-deficient DLBCLs irrespective of the molecular subtype. Here, AKT1 is linked to aneurysmal bone cyst.