For example, one mechanism used for ovarian CSCs to acquire chemoresistance is mediated by the high expression of Bclxl, and IL-6 secreted by the adipocyte increases the levels of Bclxl in chemosensitive ovarian cancer cells using the same mechanism used by ovarian CSC enhancing the proliferation, sphere formation, and tumorigenesis of ovarian cancer cells [54]. The gene discussed is BCL2L1; the disease is ovarian carcinoma.