Alvero and colleagues demonstrated that CD44+ ovarian cancer cells, another subpopulation of ovarian cancer cells with stem-like properties different from CD133+ ovarian cancer cells, have the capability to be differentiated into a CD44+/VE-cadherin+/CD34+ cells phenotype and mimic the behavior of normal endothelial cells forming vessel-like structures in a VEGF-independent manner [58]. The gene discussed is CDH5; the disease is ovarian carcinoma.