Cui and collaborators showed that myeloid-derived suppressor cells (MDSCs), components of the tumor microenvironment, stimulate the expression of miRNA-101 in ovarian cancer cells and subsequently repress the corepressor gene C-terminal binding protein-2 (CtBP2), resulting in an increase in cancer cell stemness and metastatic and tumorigenic potential [78]. The gene discussed is CTBP2; the disease is ovarian carcinoma.