In the present study, we analyzed the diagnostic values of GPR for significant liver fibrosis (≥F2), advanced liver fibrosis (≥F3) and liver cirrhosis (F4) in CHB patients in China and compared the diagnostic performances of GPR with other NITs including APRI, FIB-4, NLR, AAR and RPR. The gene discussed is ALDH18A1; the disease is Hepatic fibrosis.