Furthermore, several novel models based on blood or serum parameters such as AST/alanine aminotransferase (ALT) ratio (AAR), neutrophil-to-lymphocyte ratio (NLR) and red cell distribution width (RDW)-to-platelet ratio (RPR) have been proposed to predict significant fibrosis and cirrhosis over the past decade in CHB patients with relatively high accuracy18. The gene discussed is GPT; the disease is Cirrhosis.