Previous studies have also shown suppression of MMPs in response to IFN-γ, such as MMP-9, which like MMP-1 and MMP-3, also contains AP-1 sites (two) and putative SBEs58–60, and has been shown to be repressed following IFN-γ treatment in astrocytes, fibrosarcomas, and monocytes. The gene discussed is FOS; the disease is fibrosarcoma.