Similar to the effects we observed on murine MLL-AF9 AML cells, IL4 stimulation of MA9 cells resulted in suppression of cell proliferation (Supplementary Figure 11a), increased apoptosis via Caspase-3 activation and STAT6 phosphorylation (Figures 7a and b and Supplementary Figure 11b). This evidence concerns the gene KMT2A and acute myeloid leukemia.