Consistent with this, 35 genes near or overlapping the 37 bidirectional selection regions (Supplementary Table S7), there are genes affecting appetite (NMU, CAPS)44, 45, and associated with hyperglycemia and type-2 diabetes (AP3S2, SF3A3, ARPIN, RPL36,and NR3C2). Here, AP3S2 is linked to type 2 diabetes mellitus.