The importance of GPIHBP1 in triglyceride metabolism was demonstrated by Beigneux et al. 11 in mice, who showed that GPIHBP1-knockout (GPIHBP1−/−) mice displayed severe hypertriglyceridemia, even on a low-fat diet, exhibiting a plasma triglyceride level of 1000–6000 mg/dl at 7–10 weeks of age. The gene discussed is GPIHBP1; the disease is hypertriglyceridemia.