CCR7 and breast carcinoma: Given that the level of CCR7-dependent signaling was accompanied by CCR7 homodimerization in multiple cell types including primary human T cells and breast cancer cells, CCR7-dependent cell migration may be controlled by CCR7 homodimerization in various biological contexts, such as lymphocyte trafficking1, 3 and CCR7-dependent metastatic progression in tumors39–41.