Interestingly, the VHL at the early follow-up after 2 weeks showed only a reduction in \documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$${{\rm{\Delta }}{\rm{R}}}_{2,\text{SE}}^{3/2}$$\end{document}ΔR2,SE3/2, i.e. a therapeutic effect in the small microvasculature of the tumor (blue-framed VHLs in Fig. 3b). This evidence concerns the gene VHL and neoplasm.