The NOV (nephroblastoma overexpressed) gene (also known as CCN3) is a new member of the CCN family of secreted, extracellular matrix (ECM)-associated regulatory factors that are involved in internal and external cell signaling and play a role in angiogenesis and osteogenesis, and in the control of cell proliferation and differentiation47, 48, even against human adrenocortical tumor cells49. The gene discussed is CCN3; the disease is Nephroblastoma.