The average number of metastatic nodules was 4.11 ± 1.64 in the miR-596+CLDN4 group and 4.57 ± 1.38 in the miR-3620-3p+CLDN4 group, showing a rescue of the tumor-promoting effects caused by CLDN4 overexpression. This evidence concerns the gene CLDN4 and neoplasm.