VCP and familial amyotrophic lateral sclerosis: Mutations in p97 have been associated with familial amyotrophic lateral sclerosis and inclusion body myopathy associated with Paget's disease of bone and frontotemporal dementia (IBMPFD), a multisystem disease that is associated with abnormally active p97 on a molecular level leading to neurodegenerative defects and muscular weakness at the physiological level [10,11].