MtDNA haplogroups have also been analysed in relation to coronary artery disease (Kofler et al., 2009, Chinnery et al., 2010), diabetes (Chinnery et al., 2007), lipid profiles (Hulgan et al., 2011), blood pressure (Rea et al., 2013), obesity (Nardelli et al., 2013), CRP (Kofler et al., 2009), and many others (Samuels et al., 2006), but consensus amongst findings is limited, and well-powered studies are needed to detect these effects (Samuels et al., 2006). The gene discussed is CRP; the disease is obesity due to melanocortin 4 receptor deficiency.