They identified mutations in neurogenic locus notch homolog protein 1 (NOTCH1) as well as CNVs in MYB proto-oncogene like 2 (MYBL2) and microRNA-4707-5p, and subsequently validated the prognostic values of these genes based on the expression profiles of an independent retrospective ESCC cohort [7]. The gene discussed is NOTCH1; the disease is esophageal squamous cell carcinoma.