As the association of HOTTIP rs1859168 with the risk of PC has been demonstrated in this work, combined with the fact that HOTTIP expression was significantly related to the occurrence and development of PC, we hypothesize that HOTTIP rs1859168 polymorphism may affect the HOTTIP expression by altering its transcript activity and consequently correlate with the PC risk. The gene discussed is HOTTIP; the disease is pachyonychia congenita.