Considering the vital roles of lncRNAs for cancer development, we enforced a two-stage case-control study to evaluate the associations of three common SNPs (HOTTIP rs1859168 A > C, HOTAIR rs4759314 A > G, and H19 rs217727 C > T) in key lncRNAs genes with PC risk in China, and explore the biological mechanism of the SNPs. The gene discussed is H19; the disease is pachyonychia congenita.