CREBBP and acute myeloid leukemia: For example, ALL 542-PA and ALL 542-RD had mutations in CREBBP (p.L161 fs) and ABL1 (p.T315I; present in 73 samples in COSMIC) genes, while AML 800-PA and AML 800-RD supported a mutation in the TP53 gene (p.R273C; present in 142 COSMIC samples).