Tumour-associated B-cells induce and regulate T-cell immune responses through antigen presentation and CD4+ T-cell activation, contributing to the differentiation of CD4+ T-cells and polarisation of Th1 and Th2 subsets (Lund and Randall, 2010; Baumgarth, 2011; Bao et al 2014). The gene discussed is CD4; the disease is neoplasm.