This gene not only exists on pathways involved in aging and longevity such as MAPK signaling (hsa04010) and PI3K-Akt signaling (hsa04151), but it also exists on the following signaling pathways: leishmaniasis (hsa05140), malaria (hsa05144), toxoplasmosis (hsa05145), amoebiasis (hsa05146), tuberculosis (hsa05152), hepatitis B (hsa05161), measles (hsa05162), inflammatory bowel disease (hsa05321), rheumatoid arthritis (hsa05323), etc. TRL2 is clearly related to signaling pathways involved in aging and infection. This evidence concerns the gene AKT1 and infection.