This gene not only exists on pathways involved in aging and longevity such as MAPK signaling (hsa04010) and PI3K-Akt signaling (hsa04151), but it also exists on the following signaling pathways: leishmaniasis (hsa05140), malaria (hsa05144), toxoplasmosis (hsa05145), amoebiasis (hsa05146), tuberculosis (hsa05152), hepatitis B (hsa05161), measles (hsa05162), inflammatory bowel disease (hsa05321), rheumatoid arthritis (hsa05323), etc. TRL2 is clearly related to signaling pathways involved in aging and infection. This evidence concerns the gene AKT1 and rheumatoid arthritis.