In our exome-wide association analysis of the ALL cohort, we identified two SNPs on chromosome 10 within the ARID5B gene that were significantly associated with ALL risk: rs10821936 (RR = 2.31, 95% CI = 1.70–3.14, p = 1.70 × 10−8) and rs7089424 (RR = 2.22, 95% CI = 1.64–3.01, p = 5.19 × 10−8) (Fig 1 and Table 2). Here, ARID5B is linked to acute lymphoblastic leukemia.