The differentially expressed genes between PC subtypes also produced distinctive TFBS predictions: E2F, the CCAAT-binding factor NF-Y, C/EBPβ, ETS factors and NF-κB sites were specific for BPC specific genes, and SRF, CREB, ARNT and E-box-related factors for TPC and BMPC common genes (Fig 5C). This evidence concerns the gene CREB1 and pachyonychia congenita.