Despite not being significantly enriched in the GO analysis, the present data also show that genes of an activator of the adrenergic pathway and a neurotransmitter receptor (ADRBK2 and GABBR1, respectively), as well as genes of endogenous cannabinoid receptors (CNR2, GPR18) are reduced during the BC to PC transition. Here, CNR2 is linked to pachyonychia congenita.