PCSK9 and familial hypercholesterolemia: Recently, two new classes of non-statin blood-lowering medications have been shown to improve clinical outcomes in addition to maximally tolerated dose of statins; ezetimibe and proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors.[42–44] These medications may play a key role in treating patients with familial hypercholesterolemia and those with statin intolerance despite holding a high CVD risk but the cost associated with these medications are also a risk that the patient and physician need to take into consideration.