PDCD1 and diffuse large B-cell lymphoma: However, prognostic significance of MHC-II expression has also been shown in patients with melanoma receiving anti-programmed cell death protein 1 (PD-1) therapy and those with diffuse large B-cell lymphoma receiving rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone [30, 31].