Although calcium mobilizers are associated with tachycardia and arrhythmias, proischemic effects, cardiac hypertrophy, apoptosis and fibrosis, and worse medium- to long-term prognosis, levosimendan enhances CO and systolic and diastolic function, promotes vasodilatation and peripheral perfusion, reduces (PCWP), alleviates symptoms of dyspnea and fatigue, and reduces levels of signifier neurohormones such as brain natriuretic peptide (BNP).10 The gene discussed is NPPB; the disease is cardiac hypertrophy.