Previous studies have revealed that dysregulated BCL9 expression is an oncogenic mechanism of Wnt pathway activation.28 BCL9 serves fundamental roles in tumor progression by increasing tumor load, metastasis, angiogenesis, and invasion through regulating Wnt target genes.29, 30 We examined BCL9 expression in HCC tissues, and found that the BCL9 levels were inversely correlated with miR-1301, supporting the hypothesis that miR-1301 downregulation may contribute to BCL9 upregulation in HCC. The gene discussed is BCL9; the disease is neoplasm.