Tumor-related inflammation and immunosuppression have been proposed as the hallmarks of cancer.20 Recently, in human GC, a subset of CD127low/− Tregs could exert immunosuppressive properties, although the detailed regulatory mechanisms were not elucidated.21 In our case, we subsequently identified a novel regulatory mechanism for tumor-derived pro-inflammatory TNF-α: it promotes CD45RA−CCR7− Treg subset induction and downregulates HLA-DR expression by activating intracellular STAT3. This evidence concerns the gene TNF and gastric cancer.