Moreover, mice treated with no pre-cocultured CD8+ T cells/CD45RA−CCR7− Tregs, or with CD8+ T cells plus IL-10 blocking antibody-treated CD45RA−CCR7− Tregs, also showed an increased IFN-γ+ T-cell response in spleens (Figure 5b), as well as an increased CD8+ T-cell infiltration (Figure 5c) and IFN-γ expression/production (Figures 5d and e) in tumors, and a decreased tumor cell proliferation (Figure 5c) and TNF-α expression/production in tumors (Supplementary Figure 5), compared with the mice treated with CD8+ T cells plus CD45RA−CCR7− Tregs or control IgG-treated CD45RA−CCR7− Tregs. The gene discussed is CD8A; the disease is neoplasm.