CCR7 and neoplasm: Finally, we examined Treg subsets according to the expression of both CD45RA and CCR7, and found that most intratumoral Tregs displayed a CD45RA−CCR7− effector/memory phenotype (Figures 1d and e), whereas non-tumor tissue-derived Tregs displayed largely more CD45RA−CCR7+ central memory phenotype (Figures 1d and e).