CLEC14A and neoplasm: We found that extracellular HSP70-1A binds to the CLEC14a CTLD on the surface of endothelial cells and promotes CLEC14a-CTLD-mediated endothelial cell-cell contacts, suggesting that extracellular HSP70-1A secreted from tumor cells may stabilize CLEC14a to stimulate endothelial cell-cell contacts in angiogenesis [208].