CRP and Cowden disease: The same study on the correlations between LS and HBI, CRP in adult patients with isolated CD was conducted by LY and his colleagues in 2013, who showed that correlation between LS and HBI was weak (r = 0.4, P < .01) and that between LS and CRP was moderate (r = 0.58, P < .01).[24] However, no correlation between LS and Crohn's Disease Activity Index (CDAI), CRP in adult patients with quiescent small bowel CD was observed by Aggarwal et al[18] in 2011 for the first time.