HBI contains 5 variables and it is convenient and useful in the clinical assessment of CD.[12] Abbreviated Pediatric Crohn's Disease Activity Index (aPCDAI) was developed from the full PCDAI in 2003; it contains 3 history items and 3 physical examination items.[13] Both LS and aPCDAI gain adequate interobserver agreement and formal validation.[14,15] Laboratory parameters such as C-reactive protein (CRP), erythrocyte sedimentation rate (ESR),white blood count, hematocrit, and serum albumin have been all studied from past to now. This evidence concerns the gene CRP and Crohn disease.