Comparing the relationship between different genotypes of ICAM-1 gene and the clinical parameters (age, sex, tumor location, tumor size, depth of tumor invasion, migration, degree of differentiation, and Dukes staging) of CRC patients, we found that the distribution of K469E KK genotype in poorly differentiated individuals was significantly higher than that in moderately- or well-differentiated individuals (P < .05), whereas the distribution of KE + EE genotype in poorly-differentiated individuals was lower than that in moderately- or well-differentiated individuals (P > .05). The gene discussed is ICAM1; the disease is colorectal carcinoma.