ICAM1 and myocardial infarction: The polymorphism of the single nucleotide C to T, located in the sixth exon of the ICAM-1 gene (K469E), contributes to an amino acid substitution (from glutamic acid (E) to lysine (K)) in immunoglobulin-like receptors of the ICAM-1 protein.[10] The E and K alleles are 2 different alleles of the ICAM-1 gene leading to 3 potential genotypes, EE, EK, and KK.[14] A13848G, which also exists in exon 6 of ICAM-1, is found to be related to myocardial infarction.[15]