MDR-associated protein was related to individual differences and gene transfection study which suggested that MDR-associated protein may confer drug resistance by decreasing drug accumulation in the cells.[32] ICAM-1 provides critical adhesion molecules for macrophages (MF)-mediated drug resistance and it attenuates MF-mediated multiple myeloma cell drug resistance.[33] ICAM-1 gene polymorphism at K469E may have an effect on the plasmas ICAM-1 expression.[34] Therefore, ICAM-1 gene polymorphisms at K469E may be related to the MDR of CRC. This evidence concerns the gene ICAM1 and AL amyloidosis.