Some polymorphisms are considered as important factors that could contribute to the activity of DNA repair proteins.[16] ICAM-1 K469E polymorphism has been reported that it might be associated with susceptibility to many diseases, such as ischemic stroke (IS), Crohn's disease (CD), coronary heart disease (CHD), and neurocysticercosis (NCC).[17–20] The multidrug resistance (MDR) and expression of P-glycoprotein are the causes of chemotherapy failure. The gene discussed is ICAM1; the disease is coronary artery disorder.