Expression of ChREBP is regulated by various signals including glucose, AGEs, insulin, polyunsaturated fatty acids (PUFA), lipopolysaccharide (LPS), branched-chain amino acids (BCAAs), anoxia, and TGF-β.[28,31–33] Our findings suggest that ROS might regulate ChREBP expression in liver cancer cells. The gene discussed is INS; the disease is liver cancer.