In RA synovial tissues, the balance between HATs and HDACs activity is strongly shifted towards HAT activity, consistent with histone hyperacetylation [70]; hyperacetylation of histone H3 in the IL-6 promoter was shown to increase IL-6 expression by RA synovial fibroblasts [71]. The gene discussed is TMPRSS11D; the disease is rheumatoid arthritis.