The authors found 383 CpG sites (0.08% of tested CpGs), showing significant associations after correction for multiple testing including known diabetes loci, e.g. ADCY5, KCNJ11, HLA-DQA1, INS, PDX1 and GRB10. CpGs of significant cis-mQTLs were overrepresented in the gene body and outside of CpG islands. The gene discussed is INS; the disease is diabetes mellitus.