Also, as the NKG2D pathway has been described to play a potential role in certain autoimmune diseases such as diabetes, rheumatoid arthritis, multiple sclerosis, Crohn’s disease, lupus, or celiac disease (48), our new mouse model provides the ability to selectively express the NKG2D ligand in the targeted tissue with the corresponding Cre transgenic mouse. This evidence concerns the gene KLRK1 and rheumatoid arthritis.