PinX1 expression was correlated with sex (P = 0.020, increased in men), smoking status (P = 0.034, increased in smokers), histological type (P < 0.001, increased in SCC), recurrence and metastasis after resection (P = 0.023, decreased in the presence of metastasis), and lymph node metastasis (P = 0.033, increased for N0). The gene discussed is PINX1; the disease is metastasis.