However, studies have shown that ATG4 can be regulated by miR-34a that specifically targets ATG4B,11 miR-376b that target intracellular levels of ATG4C,12 and the tumor suppressor miR-101 that inhibits autophagy by targeting ATG4D.13 At the functional level, the biological role of ATG4D in gynecologic tumor biogenesis and progression is not well understood. Here, ATG4C is linked to female reproductive system neoplasm.