ATG4C and neoplasm: However, studies have shown that ATG4 can be regulated by miR-34a that specifically targets ATG4B,11 miR-376b that target intracellular levels of ATG4C,12 and the tumor suppressor miR-101 that inhibits autophagy by targeting ATG4D.13 At the functional level, the biological role of ATG4D in gynecologic tumor biogenesis and progression is not well understood.