LAMP-1 and LAMP-2 deficiency in various metabolic conditions, neurodegenerative diseases and infectious diseases is linked with the accumulation of autophagosomes.21–23 We hypothesized that defective fusion of the lysosome and autophagosome could impair the clearance of damaged organelles and aggregated proteins in fibroid cells likely leading to increased cell proliferation. This evidence concerns the gene LAMP1 and neurodegenerative disease.