HFE and hemochromatosis type 1: To investigate the function of hemochromatosis-related genes in response to acute bacterial infection, we administered an intraperitoneal (i.p.)injection of a lethal dose of the Gram-negative bacterium Salmonella typhimurium (S. typhimurium) [5, 18 ] to the following hemochromatosis mouse models: Hfe-knockout (Hfe−/−) mice (Figure 1a), hemojuvelin-knockout (Hjv−/−) mice (Figure 1b), and macrophage-specific ferroportin1-knockout (Fpn1fl/fl;LysM-Cre+) mice (Figure 1c).