IL18R1 and asthma: These include the locus ORMDL3, ADAM33, and several cytokine or cytokine receptor genes (IL-18R1, IL-333, IL-2RB, IL-10, TGFB, and IL-6R).[93] The genes for IL-33 and TSLP have emerged as two of the most important associations for the development of the asthma.[87] Pharmacogenomics, play an important role in the efficacy and concentration of the drug.