Allergen-specific IgE (sIgE) and skin prick test (SPT) are both common markers for atopic disease.[19] Aeroallergen sensitization (measured either by SPT or sIgE) at the age of 2 may be a useful predictor for later allergy-related disease, like asthma, with a frequent onset at the age of 6 years.[18,20] Aeroallergen sensitization and egg sensitization during infancy has been demonstrated to be associated with an increased risk of asthma at 5 years of age.[21]. The gene discussed is IGHE; the disease is asthma.