Atopy has been generally accepted as a risk factor for asthma onset, severity and worse prognosis in pediatric asthma.[17] Therefore, sensitization to allergens, resolved by skin prick test (SPT) or specific IgE (sIgE), is a marker for a long-term presence of allergy disease, such as atopic dermatitis, allergic rhinoconjunctivitis and/or asthma.[18]. Here, IGHE is linked to asthma.