To explore whether low-dose chidamide might influence the cytotoxicity of chemotherapy agents in leukemia stem cell-like cells (LSC-like cells), we investigated the anti-proliferative activities of IDA, DNR, or Ara-C alone or in combination with 0.75 μM chidamide in CD34+CD38− KG1α cells by CCK-8 assay at 24-, 48-, and 72-h treatments. Here, CD34 is linked to leukemia.