The present study data also indicates that circulating ZAG correlates positively with age, HDL-C, and HOMA-β and negatively with parameters of adiposity (WHR, FAT% and BMI), IR (increased fasting insulin and HOMA-IR), dyslipidemia (increased TG and FFA), DBP, and SBP. The gene discussed is AZGP1; the disease is metabolic syndrome.