Notoginsenoside increased synthesis of ACh by inhibiting AChE activity in the brain of rats, thereby improving learning and memory [16, 17]. L. barbarum polysaccharides could inhibit various pathological indicators of Alzheimer's disease, such as reducing Aβ and glutamate toxicities, inhibiting Tau protein phosphorylation, and suppressing apoptosis [18, 19]. Here, MAPT is linked to early-onset autosomal dominant Alzheimer disease.