LRP1 and Alzheimer disease: When stratified by time of AD onset, we found T allele of LRP1 C766T may act as a protective factor for late onset of AD (LOAD) (T versus C: OR = 0.858, 95% CI = 0.748–0.985, P = 0.029; TT + CT versus CC: OR = 0.871, 95% CI = 0.763–0.994, P = 0.040) (Fig. 4), but no significant association was observed for early onset of AD (EOAD).