Finally, regarding those 23 variants do not detected in healthy population, 9 have been associated with AIDs, and 14 have not been associated with any disease neither in clinical databases nor in journal publications, 7 of which are new (not found in any sequencing database): MEFV p.Leu367Val, NOD2 p.Val733Leu and p.Val816Ile, PSTPIP1 p.Val122Ile and p.Asp289His and TNFRSF1A p.His155Tyr and p.Asn336His (Table 1 and Figure S2B). Here, NOD2 is linked to AIDS.