NOD2 and AIDS: Regarding the 34 variants with MAF between 0 and 0.05 in healthy population, 2 have been described as non-pathogenic polymorphisms although functional effects have been reported in some cases25–27 (NLRP3 p.Glu703Lys and NOD2 p.Val955Ile, MAF in healthy population 0.02 and 0.03, respectively), 28 have been associated with different AIDs and 4 are not found in any clinical database or report.