RHEB and infection: As inhibiting the FOXO transcription factor (either directly through FOXO RNAi or indirectly through p38a RNAi) revealed the most drastic reduction in pheromone production after infection (Fig. 2e), we next activated the Rheb gene (part of the target of rapamycin signaling pathway, and which is an inhibitor of the product of FOXO)17, 41, 42.