In a human correlate of these observations, we evaluated the LGRC dataset, where we found a 12% reduction in median TSP1 expression relative to nonfibrotic controls (U = 3339; Z = 5.513; P < 0.0001, Figure 6C), a finding that was confirmed in the second dataset (GSE24206) where a 0.52-fold reduction in TSP1 was observed in samples from the IPF lung (P < 0.0001, data not shown). This evidence concerns the gene THBS1 and idiopathic pulmonary fibrosis.