In healthy adults or in MS patients greater than 10 years following lymphocyte depletion, a smaller portion of naive CD4+ cells produced IL-8, but we also noted that the level of CR2 on a per-cell basis is much lower on CR2+ naive T cells from adults as compared with the level of CR2 expression observed on CR2+ naive T cells present in neonates, children, and adults actively reconstituting their immune system. Here, CR2 is linked to myeloid sarcoma.