In this report, we present results of analyses based on testing of whether circulating levels of biomarkers representative of two main biologic pathways, endothelial dysfunction (angiopoietin 1 [Ang-1], angiopoietin-2 [Ang-2], angiopoietin ratio [Ang-2/Ang-1], soluble vascular cell adhesion molecule [sVCAM]) and inflammation/apoptosis (soluble Fas [sFas], soluble tumor necrosis factor receptor 1 [sTNFR-1], interleukin-6 [IL-6], and IL-8), are differentially associated with AKI subphenotypes in a cohort of ICU patients with the systemic inflammatory response syndrome (SIRS). The gene discussed is TNFRSF1A; the disease is endothelial dysfunction.