Third, our findings of associations between markers of endothelial dysfunction and the nonresolving AKI subphenotype in patients with septic shock support prior work demonstrating the protective effect of Ang1/Tie2 agonists in animal models of organ dysfunction in sepsis [44], and they suggest that targeting this pathway may have more of an impact in subjects with septic shock at risk for the nonresolving AKI subphenotype. Here, TEK is linked to acute kidney injury.