ANGPT1 and endothelial dysfunction: Third, our findings of associations between markers of endothelial dysfunction and the nonresolving AKI subphenotype in patients with septic shock support prior work demonstrating the protective effect of Ang1/Tie2 agonists in animal models of organ dysfunction in sepsis [44], and they suggest that targeting this pathway may have more of an impact in subjects with septic shock at risk for the nonresolving AKI subphenotype.