EZH2 and malignant peripheral nerve sheath tumor: Both downregulation of EZH2 by si/shRNA or pharmacological inhibition of EZH2 in the S462 (NF1-derived MPNST) and MPNST724 (spontaneous MPNST) cell lines severely affected cellular proliferation rates, induced apoptosis and interfered with tumor formation in an MPNST724 xenograft model.