Interestingly, de Raedt and colleagues provided evidence that BRD4 inhibition by JQ1 exerted only a modest, cytostatic effect on human MPNST cell lines and that only the combination of JQ1 with PD-901, a MEK-inhibitor, caused a tumor growth inhibition and regression [24]. The gene discussed is MAP2K7; the disease is malignant peripheral nerve sheath tumor.