All four NF1-associated MPNST cell line (sNF96.2, ST88-14, T265 and 90-8TL) and one sporadic MPNST cell line (STS26T) were more sensitive to doxorubicin than the neurofibroma Hs53.T cells, many of them displaying IC50 values of less than 50 ng/ml (Fig 6A and 6B). This evidence concerns the gene NF1 and malignant peripheral nerve sheath tumor.