Rett syndrome (RTT) causes intellectual disability [1,2] in 1 out of every 10,000 females worldwide, and is caused ~95% of the time by mutations in the X chromosomal gene MECP2 that encodes for methyl-CpG-binding protein 2 (MeCP2) [3,4]. The gene discussed is MECP2; the disease is atypical Rett syndrome.