For example, let us consider the following variants: Y482C, in ATP-binding cassette sub-family A member 1, which causes High-density lipoprotein deficiency; Y72C, in Hypoxanthine-guanine phosphoribosyltransferase, which causes hyperuricaemia and chronic tophaceous gout, and W453R, in Cytochrome b-245 heavy chain, which causes X-linked Chronic Granulomatous disease. This evidence concerns the gene HPRT1 and chronic granulomatous disease.