ROR1 and B-cell chronic lymphocytic leukemia: Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is a surface antigen present at high levels on an array of hematological malignancies and solid tumors, including pancreatic,14,15 ovarian,14-18 breast,14,19-21 lung,14,22,23 and gastric cancer24 as well as melanoma,25,26 Ewing sarcoma,27 chronic lymphocytic leukemia,28-31 mantle cell lymphoma,32,33 and a subset of B-ALL.34